Biosphere offers comprehensive scale-up solutions, ensuring a smooth transition with a high level of success in maintaining production yields and process robustness. Hence, our 150 L and 1,500 L fermentation units ensure effective scale-up to obtain robust, reproducible, fully implemented industrial processes, and all downstream unit operations can be scaled-up accordingly.

Scale-up solutions from lab to industrial scale is a key step in the development of innovative technologies for transferring laboratory-scale Proof-Of-Concept results to an industrial environment means ensuring replicability from batch to batch and introducing the right operational solutions to reduce failure rate.

During the journey of bringing new technologies to market, the scale-up phase is essential for gathering significant data on both technical feasibility and economic viability. Key factors like energy and water consumption can be reliably measured, laboratory chemicals are replaced with bulk raw materials, and potential challenges are identified and addressed. Additionally, product prototypes are produced in relevant quantities, enabling kilo-lab testing and comprehensive chemical and microbiological characterization.

All data from scale-up batches are meticulously documented, allowing for a complete definition of the fermentation and downstream protocols. These protocols can then be applied to Contract Manufacturing campaigns within our facilities or transferred to other CMOs.